As interest in proton therapy has grown, research has accelerated rapidly as demonstrated by the number of citations for protons in the prestigious International Journal of Radiation Oncology alone. Of the 740 citations in the Red Journal since 1995, 422 of them were cited between January 2006 and November 2009.

Learn More About the Clinical Literature for:
General Proton Therapy	Secondary Malignancy Risk
Prostate	Lung
Brain	Head and Neck
Pediatric	Base of Skull
Eye

PROTON THERAPY - GENERAL

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DeLaney T. and Kooy H.
Proton and charge particle radiotherapy.
Lippincott Williams & Wilkins 2008.

Fowler, J.
What can we expect from dose escalation using proton beams?
Clinical Oncology. 2003; 15: S10-S15.

Greco C. and Wolden S.
Current status of radiotherapy with proton and light ion beams.
Cancer. 2007; 109(7): 1227-38.

Jagsi R., DeLancy T., Donelan K. and Tarbell N.
Real-time rationing of scarce resources: the Northeast Proton Therapy Center experience.
Journal of Clinical Oncology. 2004; 22(11): 2246-50.

Jones B. and Price P.
Proton therapy: expanding clinical indications.
Clinical Oncology. 2004; 16(5): 324-25.

Jones B. and Errington R.
Proton beam radiotherapy.
British Journal of Radiology. 2000; 73(872): 802-05.

Lomax A., Bortfeld T., Goitein G. et al.
A treatment planning inter-comparison of proton and intensity modulated photon radiotherapy.
Radiotherapy Oncology. 1999; 51(3): 257-71.

MacDonald S., DeLaney T. and Loeffler J.
Proton beam radiation therapy.
Cancer Investigation. 2006; 24: 199-208.

Slater J.
Clinical applications of proton radiation treatment at Loma Linda University: review of a fifteen-year experience.
Technology in Cancer Research Treatment. 2006; 5(2): 81-9.

Suit H.
Protons to replace photons in external beam radiation therapy?
Clinical Oncology. 2003; 15: S29-S31.

Suit H.
The Gray Lecture 2001: Coming technical advances in radiation oncology.
International Journal Radiation Oncology Biology Physics. 2002; 53(4): 798-809.

Wilson E.
Referring patients abroad for proton therapy.
Clinical Oncology. 2000; 12(2): 71-2.

PROSTATE

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Literature Reviews

Schulte R., Slater J., Rossi C. and Slater J.
Value and perspectives of proton radiation therapy for limited stage prostate cancer.
Strahlentherapie und Onkologie. 2000; 176: 3-8.

Treatment Planning

Cella L., Lomax A. and Miralbell R.
Potential role of intensity modulated proton beams in prostate cancer radiotherapy.
International Journal Radiation Oncology Biology Physics 2001; 49: 217-23.

Mock U., Bogner J, Georg D, Auberger T and Potter R.
Comparative treatment planning on localized - prostate carcinoma conformal photon- versus proton-based radiotherapy.
Strahlentherapie und Onkologie. 2005; 7: 448-55.

Dose Escalation Studies

Dearnaley D., Sydes M., Graham J. et al.
Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial.
Lancet Oncology. 2007; 8: 475-87.

Kuban D., Tucker S., Dong L. et al.
Long-term results of the M.D. Anderson randomized dose-escalation trial for prostate cancer.
International Journal Radiation Oncology Biology Physics. 2008; 70: 67-74.

Peeters S., Heemsbergen W., Koper P. et al.
Dose-response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy.
Journal of Clinical Oncology. 2006; 24(13): 1990-96.

Zietman A., DeSilvio M., Slater J. et al.
CORRECTION: Comparison of conventional-dose vs. high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: A randomized controlled trial.
JAMA. 2008; 299: 899-900.

Zietman A., DeSilvio M., Slater J. et al.
Comparison of conventional-dose vs. high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: A randomized controlled trial.
JAMA. 2005; 294: 1233-39.

Toxicity

Storey M., Pollack A., Zagars G. et al.
Complications from radiotherapy dose escalation in prostate cancer: preliminary results of a randomized trial.
International Journal Radiation Oncology Biology Physics. 2000; 48: 635-42.

Tucker S., Dong L., Cheung R. et al.
Comparison of rectal dose-wall histogram versus dose-volume histogram for modeling the incidence of late rectal bleeding after radiotherapy.
International Journal Radiation Oncology Biology Physics. 2004; 60: 1589-1601.

Vargas C., Fryer A., Mahajan C. et al.
Dose-volume comparison of proton therapy and intensity-modulated radiotherapy for prostate cancer.
International Journal Radiation Oncology Biology Physics. 2008; 70: 744-51.

Loma Linda Experience

Slater J., Rossi C., Yonemoto L. et al.
Proton therapy for prostate cancer: the initial Loma Linda University experience.
International Journal Radiation Oncology Biology Physics. 2004; 59: 348-52.

Slater J., Yonemoto L., Rossi C. et al.
Conformal proton therapy for prostate carcinoma.
International Journal Radiation Oncology Biology Physics. 1998; 42: 299-304.

Other Clinical Outcomes

Hara I., Murakami M., Kagawa K. et al.
Experience with conformal proton therapy for early prostate cancer.
American Journal Clinical Oncology. 2004; 27(4): 323-7.

Slater J., Rossi C., Yonemoto L. et al.
Conformal proton therapy for early-stage prostate cancer.
Urology. 1999; 53(5): 978-84.

Yonemoto L., Slater J., Rossi C., Antoine J. et al.
Combined proton and photon conformal radiation therapy for locally advanced carcinoma of the prostate; preliminary results of a phase I/II study.
International Journal Radiation Oncology Biology Physics. 1997; 37: 21-9.

BRAIN

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Treatment Planning

Baumert B., Lomax A., Miltchev V. and Davis J.
A comparison of dose distributions of proton and photon beams in stereotactic conformal radiotherapy of brain lesions.
International Journal Radiation Oncology Biology Physics. 2001; 49(5): 1439-49.

Bolsi A., Fogliata A. and Cozzi L.
Radiotherapy of small intracranial tumours with different advanced techniques using photon and proton beams: a treatment planning study.
Radiotherapy Oncology. 2003; 68(1): 1-14.

Clinical Outcomes

Arteriovenous malformations (“AVMS”)

Amin-Hanjani S., Ogilvy C., Candia G., Lyons S. and Chapman P.
Stereotactic radiosurgery for cavernous malformations: Kjellberg's experience with proton beam therapy in 98 cases at the Harvard Cyclotron.
Neurosurgery. 1998; 42(6): 1229-36; Discussion 1236-8.

Kjellberg R., Hanamura T., Davis K., Lyons S. and Adams R.
Bragg-peak proton-beam therapy for arteriovenous malformations of the brain
New England Journal of Medicine. 1983; 309: 269-74.

Vernimmen F.
15 years of proton radiosurgery experience at iThemba Labs, long term results for AVMs, meningiomas, and acoustic neuromas.
Particle Therapy Cooperative Group. 2008; O2: 4.

Vernimmen F., Slabbert J, Wilson J, Fredericks S and Melvill R.
Stereotactic proton beam therapy for intracranial arteriovenous malformations.
International Journal Radiation Oncology Biology Physics. 2005; 62(1): 44-52

Meningiomas

Noel G., Bollet M., Calugaru V. et al.
Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons.
International Journal Radiation Oncology Biology Physics. 2005; 62: 1412-22.

Noel G., Habrand J., Mammar H. et al.
Highly conformal therapy using proton component in the management of meningiomas. Preliminary experience of the Centre de Protontherapie d'Orsay.
Strahlentherapie und Onkologie. 2002; 178(9): 480-5.

Vernimmen F., Harris J., Wilson J. et al.
Stereotactic proton beam therapy of skull base meningiomas.
International Journal Radiation Oncology Biology Physics. 2001; 49(1): 99-105.

Weber D., Lomax A., Rutz H., Stadelmann O. et al.
Spot-scanning proton radiation therapy for recurrent, residual or untreated intracranial meningiomas.
Radiotherapy Oncology. 2004; 71(3): 251-8.

Wenkel E., Thorton A., Finkelstein D. et al.
Benign meningiomas: partially resected, biopsied and recurrent intracranial tumors treated with combined proton and photon radiotherapy.
International Journal Radiation Oncology Biology Physics. 2000; 48: 1363-70.

Side Effects

Arteriovenous malformations (“AVMS”)

Barker F., Butler W., Lyons S. et al.
Dose-volume prediction of radiation-related complications after proton beam radiosurgery for cerebral arteriovenous malformations.
Journal Neurosurgery. 2003; 99(2): 254-63.

PEDIATRIC

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Treatment Planning

Fuss M., Hug E., Schaefer R. et al.
Proton radiation therapy for pediatric optic pathway gliomas: comparison with 3D planned conventional photons and a standard photon technique.
International Journal Radiation Oncology Biology Physics. 1999; 45(5): 1117-26.

Krengli M., Hug E., Adams J. et al.
Proton radiation therapy for retinoblastoma: comparison of various intraocular tumor locations and beam arrangement.
International Journal Radiation Oncology Biology Physics. 2005; 61: 583-93.

Lee C., Bilton S., Famiglietti R. et al.
Treatment planning with protons for pediatric retinoblastoma, medulloblastoma and pelvic sarcoma: how do protons compare with other conformal techniques.
International Journal Radiation Oncology Biology Physics. 2005; 63: 362-72.

Lin R., Hug E., Schaefer R. et al.
Conformal proton radiation therapy of the posterior fossa: a study comparing protons with three-dimensional planned protons in limiting dose to auditory structures.
International Journal Radiation Oncology Biology Physics. 2000; 48: 1219-26.

Miralbell R., Lomax A. and Russo M.
Potential role of proton therapy in the treatment of pediatric medulloblastoma/primitive neuro-ectodermal tumors: spinal theca irradiation.
International Journal Radiation Oncology Biology Physics. 1997; 38: 805-11.

St. Clair W., Adams J., Bues M. et al.
Advantages of proton compared to conventional x-ray or IMRT in the treatment of a pediatric patient with medulloblastoma.
International Journal Radiation Oncology Biology Physics. 2004; 58: 727-34.

Clinical Outcomes

Habrand J., Mammar H., Ferrand R. et al.
Proton beam therapy in the management of CNS tumors in childhood.
Strahlentherapie und Onkologie. 1999; 175(S2): 91-4.

Habrand J., Schneider R., Alapetite C. et al.
Proton therapy in pediatric base and cervical canal low-grade bone malignancies.
International Journal Radiation Oncology Biology Physics. 2008; 71: 672-75.

Hug E., Muenter M., Archambeau J. et al.
Conformal proton radiation therapy for pediatric low-grade astrocytomas.
Strahlentherapie und Onkologie. 2002; 178: 10-17.

Hug E., Sweeney R., Nurre P. et al.
Proton radiotherapy in management of pediatric base of skull tumors.
International Journal Radiation Oncology Biology Physics. 2002; 52: 1017-24.

Luu Q., Loredo L., Archambeau O. et al.
Fractionated proton radiation treatment for pediatric craniopharyngioma: preliminary report.
Cancer Journal. 2006; 12: 155-59.

MacDonald S., Safai S., Trofimov A. et al.
Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons.
International Journal Radiation Oncology Biology Physics. 2008; 71: 979-86.

McAllister B., Archambeau J., Nguyen M. et al.
Proton therapy for pediatric cranial tumors: preliminary report on treatment and disease-related morbidities.
International Journal Radiation Oncology Biology Physics. 1997; 39: 455-60.

Noel G., Habrand J., Helfre S. et al.
Proton beam therapy in the management of central nervous system tumors in childhood: the preliminary experience of the Centre de Protontherapie d'Orsay.
Medical Pediatric Oncology. 2003; 40: 309-15.

Rutz H., Weber D., Goitein G. et al.
Postoperative spot-scanning proton radiation therapy for chordoma and chondrosarcoma in children and adolescents: initial experience at Paul Scherrer Institute.
International Journal Radiation Oncology Biology Physics. 2008; 71: 220-25.

Yock T., MacDonald S., Safai S. et al.
Proton radiotherapy for ependymoma: initial outcomes and dose comparisons for intensity modulated radiation with photons, proton radiation and intensity modulated proton therapy.
International Journal Radiation Oncology Biology Physics. 2007 ASTRO; S575.

Yock T., Schneider R., Friedmann A. et al.
Proton radiotherapy for orbital rhabdomyosarcoma: clinical outcome and a dosimetric comparison with photons
International Journal Radiation Oncology Biology Physics. 2005; 63: 1161-68.

Yuh G., Loredo L., Yonemoto L. et al.
Reducing toxicity from craniospinal irradiation: using proton beams to treat medulloblastoma in young children.
Cancer Journal. 2004; 10: 386-90.

Side Effects

Chen Y., Adams J., Yock T. et al.
Improved hearing outcomes from cochlear dose reduction using proton posterior fossa boost in pediatric medulloblastoma.
International Journal Radiation Oncology Biology Physics. 2007 ASTRO; S579.

Merchant T., Hua C., Shukla H. et al.
Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models and dose characteristics and their relationship to cognitive function.
Pediatric Blood Cancer. 2008; 51: 110-17.

Mirabell R., Lomax A., Cella L. and Schneider U.
Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors.
International Journal Radiation Oncology Biology Physics. 2002; 54: 824-29.

Additional Articles

Krejcarek S., Grant P., Henson J. et al.
Physiological and radiographic evidence of the distal edge of the proton beam in craniospinal irradiation.
International Journal Radiation Oncology Biology Physics. 2007; 68: 646-49.

Kirsch D., Tarbell N.
New technologies in radiation therapy for pediatric brain tumors: the rationale for proton radiation therapy.
Pediatric Blood Cancer. 2004; 42: 461-4.

Lundkvist J., Ekman M., Ericsson S. et al.
Cost-effectiveness of proton radiation in the treatment of childhood medulloblastoma.
Cancer. 2005; 103: 793-801.

SECONDARY MALIGNANCY RISK

• TOP

Chung C., Keating N., Yock T. and Tarbell N.
Comparative analysis of second malignancy risk in patients treated with proton therapy versus conventional photon therapy.
International Journal Radiation Oncology Biology Physics. 2008; 72: S8.

Fontenot J., Lee A., Newhauser W.
Risk of secondary malignant neoplasms from proton therapy and intensity-modulated x-ray therapy for early-stage prostate cancer.
International Journal Radiation Oncology Biology Physics. 2009; 74: 616-22

Hall E.
Intensity-modulated radiation therapy, protons and the risk of second cancers.
International Journal Radiation Oncology Biology Physics. 2006; 65: 1-7.
(Read in conjunction with Gottschalk’s “Neutron dose in scattered and scanned proton beams: in regards to Eric J. Hall.” Int. J. Radiation Oncology Biology Physics 2006; 66: 1594)

Newhauser, W., Fontenot J., Mahajan A. et al.
The risk of developing a second cancer after receiving craniospinal proton irradiation
Physics in Medicine and Biology. 2009; 54: 2277-91.

LUNG

• TOP

Treatment Planning

Chang J., Zhang X., Wang X. et al.
Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in stage I or stage III non-small-cell lung cancer.
International Journal Radiation Oncology Biology Physics. 2006; 65: 1087-96.

Kang Y., Zhang X., Wang H. et al.
4D Proton treatment planning strategy for mobile lung tumors.
International Journal Radiation Oncology Biology Physics. 2007; 67: 906-14.

Clinical Outcomes

Bonnet R., Bush D., Cheek G. et al.
Effects of proton and combined proton/photon beam radiation on pulmonary function in patients with resectable but medically inoperable non-small cell lung cancer.
Chest. 2001; 120: 1803-10.

Bush D., Dunbar R., Bonnet R .et al.
Pulmonary injury from proton and conventional radiotherapy as revealed by CT
American Journal of Roentgenology. 1999; 172: 735-9.

Bush D., Slater J., Bonnet R. et al.
Proton-beam radiotherapy for early-stage lung cancer.
Chest. 1999; 116: 1313-19.

Bush D., Slater J., Shin B. et al.
Hypofractionated proton beam radiotherapy for stage I lung cancer.
Chest. 2004; 126: 1198-1203.

Hata M., Tokuuye K., Kagei K. et al.
Hypofractionated high-dose proton beam therapy for stage I non-small-cell lung cancer: preliminary results of a phase I/II clinical study.
International Journal Radiation Oncology Biology Physics. 2007; 68: 786-93.

Nihei K., Ogino T., Ishikura S. and Nishimura H.
High-dose proton bream therapy for stage I non-small-cell lung cancer.
International Journal Radiation Oncology Biology Physics. 2006; 65: 107-11.

Shioyama Y., Tokuuye K., Okumura T. et al.
Clinical evaluation of proton radiotherapy for non-small-cell lung cancer.
International Journal Radiation Oncology Biology Physics. 2003: 56(1): 7-13.

Side Effects

Gridley D., Bonnet R., Bush D. et al.
Time course of serum cytokines in patients receiving proton or combined photon/proton beam radiation for respectable but medically inoperable non-small cell lung cancer.
International Journal Radiation Oncology Biology Physics. 2004; 60: 759-66.

Komaki R., Sejpal S., Wei X. et al.
Reduction of bone marrow suppression for patients with stage III NSCLC treated by proton and chemotherapy compared with IMRT and chemotherapy.
Particle Therapy Cooperative Group 47. 2008; O10: 14.

Sejpal S., Komaki K., Wei X. et al.
Does proton beam radiotherapy reduce treatment related pneumonitis compared to intensity modulated related radiation therapy in patients with locally advanced non-small-cell lung cancer treated with concurrent chemotherapy.
Particle Therapy Cooperative Group 47. 2008; O17: 22.

Yorke E., Jackson A., Rosenweig K. et al.
Correlation of dosimetric factors and radiation pneumonitis for non-small-cell lung cancer patients in a recently completed dose escalation study.
International Journal Radiation Oncology Biology Physics. 2005; 63: 672-82.

HEAD AND NECK

• TOP

Literature Reviews

Chan A. and Liebsch N.
Proton radiation therapy for head and neck cancer.
Journal of Surgical Oncology. 2008; 97: 697–700.

Munzenrider J. and Liebsch N.
Proton therapy for tumors of the skull base.
Strahlentherapie und Onkologie. 1999;175(S2): 57-63.

Treatment Planning

Cozzi L., Fogliata A., Lomax A. and Bolsi A.
A treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours.
Radiotherapy Oncology. 2001; 61(3): 287-97.

Krengli M., Bourhaleb F. and Cozzi L.
Treatment planning comparison of photon IMRT, active and passive proton therapy, and carbon ion therapy for treatment of head and neck tumors.
International Journal Radiation Oncology Biology Physics. 2006; 66(3): S669.

Mock U., Georg D., Bogner J., Auberger T. and Potter R.
Treatment planning comparison of conventional, 3D conformal, and intensity modulated photon and proton therapy for paranasal sinus carcinoma.
International Journal Radiation Oncology Biology Physics. 2004; 58(1): 147-54.

Steneker M., Lomax A. and Schneider U.
Intensity modulated photon and proton therapy for the treatment of head and neck tumors.
Radiotherapy and Oncology. 2006; 80: 263-267.

Yeung D., Malyapa R., and Mendenhall W.
Dosimetric comparison of IMRT and proton therapy for head and neck tumors.
International Journal Radiation Oncology Biology Physics. 2006; 66(3); S412.

Clinical Outcomes

Chan A., Pommier P. and Deschler D.
Change in patterns of relapse after combined proton and photon irradiation for locally advanced paranasal sinus cancer.
International Journal Radiation Oncology Biology Physics. 2004; 60(1): S320.

Fitzck M., Thornton A. and Varvares M.
Neuroendocrine tumors of the sinonasal tract. Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy.
Cancer. 2002; 94(10): 2623-34.

Lin R., Slater J., Yonemoto L. et al.
Nasopharyngeal carcinoma: repeat treatment with conformal proton therapy- dose-volume histogram analysis.
Radiology. 1999; 213(2): 489-94.

Slater Jerry D., Yonemoto L, Mantik D. et al
Proton radiation for treatment of cancer of the oropharynx: early experience at Loma Linda University Medical Center using a concomitant boost technique.
International Journal Radiation Oncology Biology Physics. 2005; 62(2): 494-500.

Tokuuye K., Akine Y., Kagei K. et. al.
Proton therapy for head and neck malignancies at Tsukuba.
Strahlentherapie und Onkologie. 2003; 180(2): 96-101.

Side Effects

Chao K., Deasy J. and Markman J.
A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results.
International Journal Radiation Oncology Biology Physics. 2001; 49( 4): 907-16.

Eisbruch A., Kim H. and Terrell J.
Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer
International Journal Radiation Oncology Biology Physics. 2001; 50(3): 695-704.

BASE OF SKULL

• TOP

Literature Reviews

Hug E.
Review of skull base chordomas: prognostic factors and long-term results of proton-beam radiotherapy
Neurosurg Focus. 2001 Mar 15;10(3):E11.

Hug E. and Slater J.
Proton radiation therapy for chordomas and chondrosarcomas of the skull base.
Neurosurgery Clinics North America. 2000; 11(4): 627-38.

Igaki H., Tokuuye K., Okumura T. et al.
Clinical results of proton beam therapy for skull base chordoma.
International Journal Radiation Oncology Biology Physics. 2004; 60(4): 1120-6.

Treatment Planning

Torres M., Chang E., Mahajan A. et al.
Optimal treatment planning for skull base chordoma: photons, protons, or a combination of both?
International Journal Radiation Oncology Biology Physics. 2009 April 7; Epub ahead of print.

Clinical Outcomes

Austin-Seymour M., Munzenrider J, Goitein M. et al.
Fractionated proton radiation therapy of chordoma and low-grade chondrosarcoma of the base of the skull.
Journal of Neurosurgery. 1989; 70(1): 13-17.

DeLaney T., Liebsch N., Pedlow F. et al.
Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas.
International Journal Radiation Oncology Biology Physics. 2009; 74(3): 732-9.

Noel G., Habrand J., Mammar H. et al.
Combination of photon and proton radiation therapy for chordomas and chondrosarcomas of the skull base: the Centre de Protontherapie d'Orsay experience.
International Journal Radiation Oncology Biology Physics. 2001; 51(2): 392-8.

Rutz H, Weber D., Sugahara S. et al.
Extracranial chordoma: outcome in patients treated with function-preserving surgery followed by spot-scanning proton beam irradiation.
International Journal Radiation Oncology Biology Physics. 2007; 67(2): 512-20.

Rutz H, Weber D., Goitein G. et al.
Postoperative spot-scanning proton radiation therapy for chordoma and chondrosarcoma in children and adolescents: initial experience at Paul Scherrer institute.
International Journal Radiation Oncology Biology Physics. 2008; 71(1): 220-5.

EYE

• TOP

Bechrakis NE, Foerster MH.
Where is the superiority of proton radiation for ocular tumours?
Graefes Arch Clin Exp Ophthalmol. 2002 Jul;240(7):513-4. No abstract available.
PMID: 12269248 [PubMed - indexed for MEDLINE]

Caujolle JP, Mammar H, Chamorey E, Pinon F, Herault J, Gastaud P.
Proton Beam Radiotherapy for Uveal Melanomas at Nice Teaching Hospital: 16 Years' Experience.
Int J Radiat Oncol Biol Phys. 2009 Nov 10. [Epub ahead of print]

Chauvel P, Sauerwein W, Bornfeld N, Freidrichs W, Brassart N, Courdi A, Herault J, Pignol JP, Bondiau PY, Malandain G.
Clinical and technical requirements for proton treatment planning of ocular diseases. The SERAG (South Europe Radiotherapy Group).
Front Radiat Ther Oncol. 1997;30:133-42. No abstract available.
PMID: 9205893 [PubMed - indexed for MEDLINE]

Chauvel P, Sauerwein W, Bornfeld N, Freidrichs W, Brassart N, Courdi A, Herault J, Pignol JP, Bondiau PY, Malandain G.
Clinical and technical requirements for proton treatment planning of ocular diseases. The SERAG (South Europe Radiotherapy Group).
Front Radiat Ther Oncol. 1997;30:133-42. No abstract available.
PMID: 9205893 [PubMed - indexed for MEDLINE]

Conway RM, Poothullil AM, Daftari IK, Weinberg V, Chung JE, O'Brien JM.
Estimates of ocular and visual retention following treatment of extra-large uveal melanomas by proton beam radiotherapy.
Arch Ophthalmol. 2006 Jun;124(6):838-43.

Dendale R, Lumbroso-Le Rouic L, Noel G, Feuvret L, Levy C, Delacroix S, Meyer A, Nauraye C, Mazal A, Mammar H, Garcia P, D'Hermies F, Frau E, Plancher C, Asselain B, Schlienger P, Mazeron JJ, Desjardins L.
Proton beam radiotherapy for uveal melanoma: results of Curie Institut-Orsay proton therapy center (ICPO).
Int J Radiat Oncol Biol Phys. 2006 Jul 1;65(3):780-7. Epub 2006 May 2.

Dobler B, Bendl R.
Precise modelling of the eye for proton therapy of intra-ocular tumours.
Phys Med Biol. 2002 Feb 21;47(4):593-613.
PMID: 11900193 [PubMed - indexed for MEDLINE]

Egger Emmanuel, et al.
Eye Retention after Proton Beam Radiotherapy for Uveal Melanoma.
Int. J. Radiation Oncology Biol. Phys. 2003; 55(4): 867-880.

Fuss M, Loredo LN, Blacharski PA, Grove RI, Slater JD.
Proton radiation therapy for medium and large choroidal melanoma: preservation of the eye and its functionality.
Int J Radiat Oncol Biol Phys. 2001 Mar 15;49(4):1053-9.
PMID: 11240247 [PubMed - indexed for MEDLINE]

Gragoudas ES, Lane AM, Regan S, Li W, Judge HE, Munzenrider JE, Seddon JM, Egan KM.
A randomized controlled trial of varying radiation doses in the treatment of choroidal melanoma.
Arch Ophthalmol. 2000 Jun;118(6):773-8.

Gragoudas ES, Lane AM, Munzenrider JE, Egan KM, Li W.
Long-term risk of local failure after proton therapy for choroidal/ciliary body melanoma.
Trans Am Opthalmol Soc. 2002;100:43-8; discussion 48-9.
PMID: 12545676 [PubMed - indexed for MEDLINE]

Höcht S, Bechrakis NE, Nausner M, Kreusel KM, Kluge H, Heese J, Heufelder J, Cordini D, Homeyer H, Fuchs H, Martus P, Foerster MH, Wiegel T, Hinkelbein W.
Proton therapy of uveal melanomas in Berlin. 5 years of experience at the Hahn-Meitner Institute.
Strahlenther Onkol. 2004 Jul;180(7):419-24.

Hug EB, Adams J, Ritzek M, De Vries A, Munzenrider JE.
Fractionated, three-dimensional, planning-assisted proton-radiation therapy for orbital rhabdomyosarcoma: a novel technique.
Int J Radiat Oncol Biol Phys. 2000 Jul 1;47(4):979-84.
PMID: 10863068 [PubMed - indexed for MEDLINE]

Krengli M, Hug EB, Adams JA, Smith AR, Tarbell NJ, Munzenrider JE.
Proton radiation therapy for retinoblastoma: comparison of various intraocular tumor locations and beam arrangements.
Int J Radiat Oncol Biol Phys. 2005 Feb 1;61(2):583-93.
PMID: 15667981 [PubMed - indexed for MEDLINE]

Munzenrider JE.
Proton therapy for uveal melanomas and other eye lesions.
Strahlenther Onkol. 1999 Jun;175 Suppl 2:68-73.

Munzenrider JE.
Uveal melanomas. Conservation treatment.
Hematol Oncol Clin North Am. 2001 Apr;15(2):389-402.

Munzenrider JE., et al.
Conservative Treatment of Uveal Melanoma: Probability of Eye Retention after Proton Treatment.
Int. J. Radiation Oncology Biol. Phys. 1988; 15(3): 553-558.

Pfeiffer K, Bendl R.
Real-time dose calculation and visualization for the proton therapy of ocular tumours.
Phys Med Biol. 2001 Mar;46(3):671-86.
PMID: 11277216 [PubMed - indexed for MEDLINE]

Weber Damien C., et al.
Proton Beam Radiotherapy versus Fractionated Stereotactic Radiotherapy for Uveal Melanomas: A Comparative Study.
Int. J. Radiation Oncology Biol. Phys. 2005; 63(2): 373-384.

Weber DC, Chan AW, Lessell S, McIntyre JF, Goldberg SI, Bussiere MR, Fitzek MM, Thornton AF, Delaney TF.
Visual outcome of accelerated fractionated radiation for advanced sinonasal malignancies employing photons/protons.
Radiother Oncol. 2006 Dec;81(3):243-9. Epub 2006 Oct 16.

Weber DC, Lomax AJ, Rutz HP, Stadelmann O, Egger E, Timmermann B, Pedroni ES, Verwey J, Miralbell R, Goitein G; Swiss Proton Users Group.
Spot-scanning proton radiation therapy for recurrent, residual or untreated intracranial meningiomas.
Radiother Oncol. 2004 Jun;71(3):251-8.

Wilson MW, Hungerford JL.
Comparison of episcleral plaque and proton beam radiation therapy for the treatment of choroidal melanoma.
Ophthalmology. 1999 Aug; 106(8):1759-87.
PMID: 10442907 [PubMed - indexed for MEDLINE]

Yock Torunn, et al.
Proton Radiotherapy for Orbital Rhabdomyosarcoma: Clinical Outcome and a Dosimetric Comparison with Photons.
Int. J. Radiation Oncology Biol. Phys. 2005; 63(4): 1161-1168.

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